6533b823fe1ef96bd127dfed
RESEARCH PRODUCT
The analgesic-antiinflammatory extract fromAraujia sericifera lacks ulcerogenic activity on stress-gastric damage model
M. A. Martínez-cuestaL. MorenoJuan V. EspluguesEduardo Primo-yúferaR. Bellosubject
PharmacologyAspirinbiologyTraditional medicineExperimental modelbusiness.industryStomachAnalgesicGastric lesionsbiology.organism_classificationHexanechemistry.chemical_compoundmedicine.anatomical_structurechemistryBiochemistryToxicitymedicineAraujia sericiferabusinessmedicine.drugdescription
The present study evaluates the ulcerogenic activity of the hexane extract from dry fruits of Araujia sericifera in an experimental model of cold-restraint stress. Treatment of rats with 200 mg/kg (i.p.) of hexane extract did not affect the gastric lesions induced by cold-restraint stress. However, it was confirmed that a dose of 300 mg/kg (i.p.) of acetylsalicylic acid (ASA) which induced a similar analgesic-antiinflammatory effect, increased significantly the level of gastric damage. Thus, the hexane extract from the fruits of A. sericifera seems to possess analgesic-antiinflammatory properties which are not linked to gastrolesive effects.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-11-01 | Phytotherapy Research |