0000000000011776
AUTHOR
Eduardo Primo-yúfera
Antiinflammatory activity and effects on isolated smooth muscle of extracts from differentTeucrium species
The present study analyses the antiinflammatory effects and the action on in vitro motility of methanol and dichloromethanol extracts and stems of four Teucrium species (T. flavum, T. cartaginenses, T. buxifolium and T. pumillum). The antiinflammatory activity was tested in the carrageenan-induced paw oedema in rats. T. flavum methanol (200 mg/kg, i.p.) and dichloromethanol (138 mg/kg, i.p.) extracts showed a significant anti-inflammatory effect through the 24 h experimental period and reduced the Emax induced by histamine and serotonin in vitro on guinea-pig ileum and rat uterus respectively. These extracts did not modify the contractile effects induced by acetylcholine on rat duodenum and…
The analgesic-antiinflammatory extract fromAraujia sericifera lacks ulcerogenic activity on stress-gastric damage model
The present study evaluates the ulcerogenic activity of the hexane extract from dry fruits of Araujia sericifera in an experimental model of cold-restraint stress. Treatment of rats with 200 mg/kg (i.p.) of hexane extract did not affect the gastric lesions induced by cold-restraint stress. However, it was confirmed that a dose of 300 mg/kg (i.p.) of acetylsalicylic acid (ASA) which induced a similar analgesic-antiinflammatory effect, increased significantly the level of gastric damage. Thus, the hexane extract from the fruits of A. sericifera seems to possess analgesic-antiinflammatory properties which are not linked to gastrolesive effects.
Effects on Arterial Blood Pressure of the Methanol and Dichloromethanol Extracts from Schinus molle L. in Rats
The effects on arterial blood pressure of the methanol and dichloromethanol extracts from Schinus molle L. were analysed in urethane anaesthetized rats. In normotensive rats, the mean arterial blood pressure was significantly reduced by the i.v. administration of both extracts. The dichloromethanol extract inhibited the effects of noradrenaline on arterial blood pressure in the anaesthetized rat and it reduced the maximal contractile effect (Emax) induced by noradrenaline on rat vas deferens in the organ bath. However, the methanol extract did not modify the effects of noradrenaline in the evaluated tests.
Analgesic Activity and Effects on Isolated Smooth Muscle of Different Fractions of Hexane Extract fromAraujia sericifera Brot
The present study analyses the analgesic activity and action on in vitro motility of methanol soluble and methanol insoluble fractions obtained from the hexane extract of fruits from Araujia sericifera. The methanol fraction did not show any pharmacological activity on the different tests evaluated. However, the insoluble methanol fraction exhibited an interesting analgesic effect in models of chemical and thermal stimulus and it reduced the E max induced by histamine in vitro on guinea-pig ileum. This extract lacked any central depressor activity since it did not modify the number of mouse movements in the activity cage.
Cardiovascular effects of the methanol and dichloromethanol extracts fromTeucrium flavum L.
The effects on arterial blood pressure and heart rate of the methanol and dichloromethanol extracts from Teucrium flavumL. were analysed in urethane anaesthetized rats. Mean arterial blood pressure was significantly reduced by the i.v. administration of both extracts to normotensive rats. The methanol extract also induced a decrease in the heart rate, while the dichloromethanol extract lacked any effect on this parameter. © 1998 John Wiley & Sons, Ltd.
Evaluation of the analgesic and CNS actions of different fractions from the methanol extract ofTeucrium flavum L.
Different fractions (F.1, F-3, F-5, F-6, F-7, F-8) of the methanol extract from Teucrium flavum L. have been tested for their central nervous system and analgesic activities at a dose of 200 mg/kg. Fractions F-1, F-3 and F-7 showed CNS depressant activity, while fractions F-5, F-6 and F-8 had a slight CNS stimulant action. Fractions F-5, F-6, F-7 and F-8 were responsible for the analgesic activity of the extract.
Cardiovascular effects of the methanol and dichloromethanol extracts fromTeucrium cartaginenses L.
Methanol and dichloromethanol extracts of the leaves and stems of Teucrium cartaginensesL. have been tested for their effects on resting arterial blood pressure, heart rate and noradrenaline induced hypertension. Both extracts administered i.v. to urethane anaesthetized normotensive rats reduced mean arterial blood pressure and heart valve, while only the dichloromethanol extract prevented noradrenaline induced hypertension. © 1998 John Wiley & Sons, Ltd.
Cardiovascular effects of the methanol and dichloromethanol extracts fromMentha suaveolensEhrh.
Methanol and dichloromethanol extracts of the leaves and stems of Mentha suaveolens Ehrh. have been tested for their effects on resting arterial blood pressure, heart rate and noradrenaline induced hypertension. Both extracts administered by i.v. bolus to urethane anaesthetized normotensive rats reduced the mean arterial blood pressure and heart rate, while only the dichloromethanol extract prevented the noradrenaline induced hypertension.
Pharmacological properties of the methanol extract from Mentha suaveolens Ehrh.
The present study analyses the pharmacological activity in in vivo and in vitro models of the methanol extract obtained from the leaves and steams of Menta suaveolens Ehrh. This extract lacked toxicity, but exhibited a central nervous system depressant action; an analgesic effect in models of chemical and mechanical stimulation suggesting the induction of a peripheral analgesic response. The extract also exhibited an antiinflammatory action inhibiting the rat paw oedema induced by carrageenin. Moreover, the in vitro studies showed a significant diminution in the contractile effects induced by histamine, serotonin and acetylcholine.
Effects on arterial blood pressure of the methanol extracts from differentTeucriumspecies
Methanol extracts of the leaves and stems of two Teucrium species (T. pumillum L. and T. buxifolium L.) have been tested for their effects on resting arterial blood pressure. Both T. pumillum L. and T. buxifolium L. extracts reduced mean arterial blood pressure in a dose dependent manner when administered i.v. to urethane anaesthetized normotensive rats. © 1997 John Wiley & Sons, Ltd.
In vitro studies of methanol and dichloromethanol extracts ofJuniperus oxycedrus L.
The present study evaluated the effect of methanol and dichloromethanol extracts obtained from the leaves and stems of Juniperus oxycedrus against neurotransmitter-induced contraction in different isolated tissues of rats and guinea-pigs. Diverse concentrations of these extracts inhibit the concentration curve response to histamine, serotonin and acetylcholine. These results contribute to explaining the use of this plant in folk medicine. © 1997 John Wiley & Sons, Ltd.
Analgesic and central depressor effects of the dichloromethanol extract fromSchinus molle L.
The analgesic and central depressor effects of the dichloromethanol extract of Schinus molle L. were analysed in in vivo models. This extract showed low acute toxicity, CNS depressor activity and analgesic effect. Following further fractionation, the hexane/dichloromethane (75/25) fraction showed the most interesting results. Thus, this fraction caused a total inhibition of motor activity and significantly reduced the threshold of pain to chemical stimulus. © 1997 John Wiley & Sons, Ltd.
Globularia alypumL. extracts reduced histamine and serotonin contractionin vitro
The present study analyses in in vitro models the pharmacological activity of methanol and dichloromethane extracts (1, 10 and 100 microg/mL) obtained from the leaves and stems of Globularia alypum L. Preincubation of the guinea-pig ileum and rat uterus with both extracts produced a dose dependent abolition of the contractile effects of histamine and serotonin, respectively. At the same doses, neither methanol nor dichloromethane extract reduced the contractile effects of acetylcholine on rat duodenum or noradrenaline on rat vas deferens.