6533b828fe1ef96bd12878c8
RESEARCH PRODUCT
Analgesic Activity and Effects on Isolated Smooth Muscle of Different Fractions of Hexane Extract fromAraujia sericifera Brot
Eduardo Primo-yúferaM D BarrachinaJuan V. EspluguesM. J. Lopez De Medrano-villarR. Bellosubject
PharmacologyChromatographybiologyChemistryAnalgesicBiological activitybiology.organism_classificationIn vitroHexanechemistry.chemical_compoundBiochemistryIn vivoMethanolAraujia sericiferaHistaminedescription
The present study analyses the analgesic activity and action on in vitro motility of methanol soluble and methanol insoluble fractions obtained from the hexane extract of fruits from Araujia sericifera. The methanol fraction did not show any pharmacological activity on the different tests evaluated. However, the insoluble methanol fraction exhibited an interesting analgesic effect in models of chemical and thermal stimulus and it reduced the E max induced by histamine in vitro on guinea-pig ileum. This extract lacked any central depressor activity since it did not modify the number of mouse movements in the activity cage.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-06-01 | Phytotherapy Research |