6533b872fe1ef96bd12d2dd2
RESEARCH PRODUCT
Globularia alypumL. extracts reduced histamine and serotonin contractionin vitro
Juan V. EspluguesL. MorenoEduardo Primo-yúferaR. Bellosubject
Pharmacologymedicine.medical_specialtyVas deferensIleumBiological activityBiologyPharmacognosychemistry.chemical_compoundmedicine.anatomical_structureEndocrinologychemistryInternal medicinemedicineSerotoninSerotonin AntagonistsHistamineAcetylcholinemedicine.drugdescription
The present study analyses in in vitro models the pharmacological activity of methanol and dichloromethane extracts (1, 10 and 100 microg/mL) obtained from the leaves and stems of Globularia alypum L. Preincubation of the guinea-pig ileum and rat uterus with both extracts produced a dose dependent abolition of the contractile effects of histamine and serotonin, respectively. At the same doses, neither methanol nor dichloromethane extract reduced the contractile effects of acetylcholine on rat duodenum or noradrenaline on rat vas deferens.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-06-01 | Phytotherapy Research |