Enantioselective Synthesis of 2-Isoxazolines by a One-Flask Conjugate Addition/Oxime-Transfer Process

6533b823fe1ef96bd127e0d2

RESEARCH PRODUCT

Enantioselective Synthesis of 2-Isoxazolines by a One-Flask Conjugate Addition/Oxime-Transfer Process

subject

chemistry.chemical_compound chemistry Intramolecular force Organic Chemistry Enantioselective synthesis Organic chemistry General Chemistry Oxime Catalysis Catalysis Conjugate

description

Enantioselective isoxazoline synthesis: A combination of 1) a catalytic enantioselective conjugate addition of oximes to alpha,beta-unsaturated aldehydes and 2) an acid-catalyzed intramolecular oxime-transfer reaction lead to the first asymmetric synthesis of 3-unsubstituted 2-isoxazolines (see scheme).

year	journal	country	edition	language
2009-03-06	Chemistry - A European Journal

https://doi.org/10.1002/chem.200802684

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