6533b823fe1ef96bd127e11e
RESEARCH PRODUCT
The burden and epidemiology of community-acquired central nervous system infections: a multinational study
Recep TekinLenka BaštákováAlexandru CrisanNenad PandakEgidia MiftodeC. JekkelEjaz Ahmed KhanEva PernicováSerhat UysalA. JouharXavier ArgemiRodrigo HasbunA. PintoUgur MusabakM. AmsilliEmre GüvenNefise OztoprakL. ČAlkićArjan HarxhiM. Momen-heraviR. V. MorotiHasip KahramanSvjetlana GrgićGhaydaa A. ShehataG. ShopayevaOğuz Reşat SipahiLykke LarsenSally HargreavesB. JegorovićR. StebelZ. FehérHakan ErdemYasemin CagLurdes SantosF. MoradiA. BruzsaK. C. LungPhillip ChanGülden ErsözLjiljana Betica RadićSoner YilmazF. RigoSadie NamaniFigen KaptanMaiya KonkayevaA. DuissenovaAntonio CascioSholpan KulzhanovaHava YilmazB. UtaganovM. BaldeyrouT. TangHumera Porobic-jahicFatma Yilmaz-karadagSead AhmetagicM. NassarJ. AronAsuman InanB. LakatosHanefi Cem GulAnne Lisbeth BohrG. BellaudCumhur ArtukAhmad KhalifaA. CanestriİLhami ÇElikZauresh SmagulovaA. MoravvejiA. K. L. WuL. PraticòT. RoganovićLucrecia SalazarM. LanzafameP. BossiSelçuk Kayasubject
0301 basic medicineMaleOutcome AssessmentAdverse Clinical Outcomemedicine.disease_causeCentral nervous system infections ; burden ; epidemiologyMedical microbiologyCentral Nervous System InfectionsOutcome Assessment Health CareEpidemiology80 and overAged 80 and overbiologyAge FactorsGeneral MedicineMiddle AgedCommunity-Acquired InfectionsInfectious Diseases[SDV.MP]Life Sciences [q-bio]/Microbiology and ParasitologyPopulation SurveillanceFemaleNeuroborreliosisHuman Immunodeficiency VirusMicrobiology (medical)Adultmedicine.medical_specialtyTuberculosisSettore MED/17 - Malattie Infettive030106 microbiologyBrain AbscessCentral Nervous System InfectionNeurosyphilisMycobacterium tuberculosis03 medical and health sciencesYoung AdultInternal medicineStreptococcus pneumoniaeJournal ArticlemedicineHumansAgedRetrospective Studiesbusiness.industryVaricella zoster virusmedicine.diseasebiology.organism_classificationHealth CareCross-Sectional StudiesCentral Nervous System DiseaseBrain AbsceHuman Immunodeficiency ViruImmunologybusinessdescription
Ghaydaa, Shehata/0000-0002-3631-893X; Radic, Ljiljana Betica/0000-0002-8778-106X; Silva-Pinto, Andre/0000-0002-2077-3356; Cascio, Antonio/0000-0002-1992-1796; Bossi, Paolo/0000-0003-0135-0224; Stebel, Roman/0000-0001-6922-4465; Namani, Sadie/0000-0002-2411-8623; Chan, Phillip/0000-0002-4071-4409; Hargreaves, Sally/0000-0003-2974-4348; Artuk, Cumhur/0000-0003-0827-990X; Harxhi, Arjan/0000-0001-8518-7377; Larsen, Lykke/0000-0002-4113-4182; Uysal, Serhat/0000-0002-4294-5999 WOS: 000407582200010 PubMed: 28397100 Risk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. A total of 2583 patients with CA-CNS infections were included from 37 referral centers in 20 countries. Of these, 477 (18.5%) patients survived with sequelae and 227 (8.8%) died, and 1879 (72.7%) patients were discharged with complete cure. The most frequent infecting pathogens in this study were Streptococcus pneumoniae (n = 206, 8%) and Mycobacterium tuberculosis (n = 152, 5.9%). Varicella zoster virus and Listeria were other common pathogens in the elderly. Although staphylococci and Listeria resulted in frequent infections in immunocompromised patients, cryptococci were leading pathogens in human immunodeficiency virus (HIV)-positive individuals. Among the patients with any proven etiology, 96 (8.9%) patients presented with clinical features of a chronic CNS disease. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS tuberculosis had a predilection to present chronic courses. Listeria monocytogenes, Staphylococcus aureus, M. tuberculosis, and S. pneumoniae were the most fatal forms, while sequelae were significantly higher for herpes simplex virus type 1 (p < 0.05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 |