6533b823fe1ef96bd127eafd

RESEARCH PRODUCT

The ins and outs of osteopontin.

Sabina SangalettiClaudio TripodoMario P. ColomboClaudia Chiodoni

subject

Pathologymedicine.medical_specialtybiologymedicine.medical_treatmentImmunologyImmunosuppressionMetastasimedicine.diseaseMetastasisMammary carcinomaExtracellular matrixOncologystomatognathic systemTumor progressionMyeloid-derived suppressor cellbiology.proteinCancer researchMyeloid-derived Suppressor CellmedicineImmunology and AllergyOsteopontinOsteopontinAuthor's ViewMetastasis; Myeloid-derived suppressor cells; Osteopontin; Immunology and Allergy; Oncology; Immunology

description

The continuous remodeling of progressing tumors demands non-physiologic production of extracellular matrix (ECM) proteins. Among them, osteopontin (OPN) has been largely involved in tumor progression and metastasis. We have recently discovered a new mechanism for OPN in the metastatic spread of mammary carcinoma providing local immunosuppression at the seeding site.

yearjournalcountryeditionlanguage
2015-01-01Oncoimmunology
10.4161/2162402x.2014.978711https://pubmed.ncbi.nlm.nih.gov/25949895