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RESEARCH PRODUCT
The in Vivo Effects of Interleukin 2 (TCGF)
Martin RöllinghoffH. StötterHermann WagnerConny HardtKlaus HeegKlaus Pfizenmaiersubject
Cytotoxicity ImmunologicInterleukin 2T-LymphocytesLymphocyte CooperationImmunologyMice NudeMice Inbred StrainsIn Vitro TechniquesPharmacologyEpitopeEpitopesMiceAntigenIn vivoAnimalsImmunology and AllergyMedicineMice nudeLymphokinesbusiness.industryLymphokineHematologyLymphocyte CooperationCTL*ImmunologyInterleukin-2businessmedicine.drugdescription
This brief review of our experiments concerning the in vivo activity of crude Il-2 led us to the following conclusion: The first is the existence, in vivo, of a cyclophosphamide-sensitive T-cell controlling the activity of a serum born Il-2 inhibitor in thymus-bearing normal mice. Under in vivo conditions which are characterized by high Il-2 inhibitor activities, locally applied Il-2 administered along with antigen amplified in vivo CTL-responsiveness, yet the effect observed was poor. Crude Il-2 proved to be a potent immuno-enhancing agent in the athymic (nu/nu) mouse, which lacks Il-2 inhibitor activity. It was found that together with antigen administration of Il-2 to nude mice results in the generation of highly reactive T-helper cells, as well as in the generation of alloreactive CTL.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1982-03-01 | Immunobiology |