Red Cell Filterability and Erythrocyte Membrane Microviscosity during Ticlopidine Treatment

6533b823fe1ef96bd127ed6c

RESEARCH PRODUCT

Red Cell Filterability and Erythrocyte Membrane Microviscosity during Ticlopidine Treatment

Anna Catania Giuseppe Francavilla Serra A Antonio Sarno R. Lo Presti Gregorio Caimi

subject

Male Ticlopidine Arteriosclerosis 030204 cardiovascular system & hematology Pharmacology Biochemistry Microviscosity 03 medical and health sciences 0302 clinical medicine Erythrocyte Deformability medicine Humans Erythrocyte deformability Ticlopidine Red Cell Viscosity business.industry Erythrocyte Membrane Biochemistry (medical)Cell Biology General Medicine Arteriosclerosis medicine.disease Red blood cell Erythrocyte membrane medicine.anatomical_structure Mechanism of action Biochemistry 030220 oncology & carcinogenesis Female medicine.symptom Rheology business medicine.drug

description

The effects of 10 days' treatment with 500 mg/day ticlopidine on the filterability of red blood cells in suspension and on the microviscosity of the red blood cell membrane was evaluated in 11 patients with vascular atherosclerosis. The results show ticlopidine to be effective in influencing the rheological measures of red cell filterability and membrane microviscosity: filterability was increased and microviscosity was decreased. Ticlopidine also decreased the extent of fluorescence polarization. These results are discussed regarding possible mechanisms of action of ticlopidine.

year	journal	country	edition	language
1990-03-01	Journal of International Medical Research

https://doi.org/10.1177/030006059001800210

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