6533b823fe1ef96bd127f5ba

RESEARCH PRODUCT

Histamine binding to H2 receptors stimulates phospholipid methylation in mast cells

G. ToloneG. ToloneL. BonaseraL. BonaseraG.m. PontieriG.m. Pontieri

subject

MaleHistamine H1 receptorBiologyMethylationCellular and Molecular Neurosciencechemistry.chemical_compoundHistamine receptorHistamine H2 receptorBurimamidemedicineAnimalsReceptors Histamine H2Mast CellsHistamine H4 receptorMolecular BiologyPhospholipidsPharmacologyHistamine N-methyltransferaseHistamine bindingRats Inbred StrainsCell BiologyMast cellRatsmedicine.anatomical_structureBiochemistrychemistryReceptors HistamineMolecular MedicineCimetidineHistamineHistamine

description

Rat peritoneal mast cells incubated in vitro in the presence of L-[methyl-3H] methionine and exposed to histamine undergo a rapid but transient increase in phospholipid methylation. By using specific H1- and H2-receptor antagonists, and histamine analogues differing in their H2-receptor agonist potency, it has been demonstrated that this metabolic event is dependent on histamine binding to H2-receptors.

https://doi.org/10.1007/bf01953681