6533b823fe1ef96bd127f613

RESEARCH PRODUCT

Myeloid Cells in the Central Nervous System

Jonathan KipnisJonathan KipnisNir YogevAnthony J. FilianoAshtyn T. SmithJasmin Herz

subject

Central Nervous System0301 basic medicinePathologymedicine.medical_specialtyMyeloidNeuroimmunomodulationImmunologyCentral nervous systemBiologyInfectionsmedicine.disease_causeNeuroprotectionArticleAutoimmune DiseasesAutoimmunity03 medical and health sciencesMeningesmedicineAnimalsHumansImmunology and AllergyMyeloid CellsMicrogliaNeurodegenerationMeningesNeurodegenerative Diseasesmedicine.diseaseNeuroprotection030104 developmental biologyInfectious Diseasesmedicine.anatomical_structureChoroid PlexusImmunologyWounds and InjuriesChoroid plexus

description

The central nervous system (CNS) and its meningeal coverings accommodate a diverse myeloid compartment that includes parenchymal microglia and perivascular macrophages, as well as choroid plexus and meningeal macrophages, dendritic cells, and granulocytes. These myeloid populations enjoy an intimate relationship with the CNS, where they play an essential role in both health and disease. Although the importance of these cells is clearly recognized, their exact function in the CNS continues to be explored. Here, we review the subsets of myeloid cells that inhabit the parenchyma, meninges, and choroid plexus and discuss their roles in CNS homeostasis. We also discuss the role of these cells in various neurological pathologies, such as autoimmunity, mechanical injury, neurodegeneration, and infection. We highlight the neuroprotective nature of certain myeloid cells by emphasizing their therapeutic potential for the treatment of neurological conditions.

yearjournalcountryeditionlanguage
2017-03-29Immunity
https://doi.org/10.1016/j.immuni.2017.06.007