6533b824fe1ef96bd127fe32
RESEARCH PRODUCT
Über den Einfluss von Acetylcholin auf das Membranpotential denervierter Rattenzwerchfelle
W. PrachtH. Lüllmannsubject
PharmacologyDenervationMembrane potentialmedicine.medical_specialtyChemistryDepolarizationCell BiologyResting potentialCellular and Molecular NeuroscienceEndocrinologyInternal medicinemedicineMolecular MedicineRat DiaphragmMolecular BiologyIntracellularAcetylcholinemedicine.drugPhrenic nervedescription
The membran potential of isolated rat-diaphragms has been measured by means of intracellular micro-electrodes, in order to study changes of the resting potential and of the depolarizing action of acetylcholine after section of the phrenic nerve. Within 80 days after denervation, the membrane potential was found to fall exponentially from 87 mV to 66 mV. The action of acetylcholine, on the other hand, was found to be independent of the duration of denervation: between the 4th and the 80th day of denervation: 10−5g/ml acetylcholine always caused the membrane potential to fall by an average of the 9 mV.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1957-07-01 | Experientia |