6533b824fe1ef96bd1280123

RESEARCH PRODUCT

Tumor infiltration by chemokine receptor 7 (CCR7)+ T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer

Maria Teresa Del VecchioMaria Saveria RotundoPierpaolo CorrealePierosandro TagliaferriCirino BottaPierfrancesco Tassone

subject

Tumor microenvironmentPathologymedicine.medical_specialtyPrognostic factorColorectal cancerTumor-infiltrating lymphocytesbusiness.industryImmunologyC-C chemokine receptor type 7medicine.diseaseColorectal cancerTumor infiltrating lymphocytesChemokine receptorImmune systemOncologymedicineCancer researchImmunology and AllergyProgression-free survivalbusinessInfiltration (medical)Author's ViewCCR7

description

The immune interactions occurring within the tumor microenvironment have a critical role in determining the outcome of colorectal cancer patients. We carried-out an immunohistochemical analysis of tumor infiltrating T-lymphocytes expressing chemokine receptor 7 (CCR7) in a series of colorectal cancer patients enrolled in a prospective clinical trial. We demonstrated that a high tumor infiltration score of this lymphocyte subset is predictive of longer progression free survival and overall survival. © 2012 Landes Bioscience.

yearjournalcountryeditionlanguage
2012-07-01
10.4161/onci.19404http://hdl.handle.net/10447/512507