The effect of tacrine on acetylcholine overflow in the heart

6533b824fe1ef96bd128015b

RESEARCH PRODUCT

The effect of tacrine on acetylcholine overflow in the heart

R. Lindmar Konrad Löffelholz

subject

medicine.medical_specialty Isoflurophate Guinea Pigs In Vitro Techniques chemistry.chemical_compound Ileum Internal medicine medicine Animals Choline Acetylcholine metabolism Cholinesterase Pharmacology biology Chemistry Myocardium Heart Acetylcholine Electric Stimulation Endocrinology Mechanism of action Enzyme inhibitor Tacrine Tacrine biology.protein Field stimulation medicine.symptom Chickens Acetylcholine medicine.drug

description

Tacrine, 10(-6) M, enhanced the acetylcholine (ACh) overflow evoked in perfused chicken hearts by field stimulation (5 Hz, 1 min) from 183 to 346 pmol g-1 min-1. Increase to the same level were observed after pretreatment with diisopropylfluorophosphate (DFP) as well as after DFP plus 10(-6) M tacrine. Tacrine, 10(-5) M, caused further enhancement with or without DFP up to 851 pmol g-1 min-1. It was concluded that 10(-6) M tacrine enhanced the ACh overflow by choline esterase inhibition, whereas 10(-5) M tacrine caused, in addition, an increase of neuronal ACh release.

year	journal	country	edition	language
1990-11-06	European Journal of Pharmacology

https://doi.org/10.1016/0014-2999(90)94134-j

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