6533b824fe1ef96bd1280a5f
RESEARCH PRODUCT
Effects of cimetidine, atropine and prostaglandin E2 on rat mucosal erosions produced by intragastric distension
Salvador F. AliñoJosé M. LlorisJuan V. EspluguesEzequiel Marti-bonmatisubject
AtropineMalemedicine.medical_treatmentPharmacologyGuanidinesPepsinmedicineGastric mucosaAnimalsStomach UlcerProstaglandin E2CimetidinePharmacologyGastric Juicebiologybusiness.industryProstaglandins EGastric distensionStomachdigestive oral and skin physiologyRatsDisease Models AnimalAtropinemedicine.anatomical_structureAnesthesiabiology.proteinmedicine.symptomCimetidinebusinessProstaglandin Emedicine.drugdescription
Abstract The effects of three typical antisecretory agents: cimetidine, atrophine and prostaglandin E2 were compared on an acute rat gastric ulcer model which consisted of perfusing the stomach continuously, at a high intraluminal pressure (120 mm H2O), with a simulated gastric juice (0.1 M HCl plus 600 mg pepsin/1). As the acid and pepsin are given exogenously the inhibitory action of the antisecretory drugs is obviated in this model. Cimetidine and atropine failed to reduce gastric erosions, whereas prostaglandin E2 markedly reduced the severity of the mucosal lesions with respect to control values. Long-term treatment with cimetidine also failed to increase the resistance of the gastric mucosa to the digestive action of the artificial gastric juice. These findings indicate that only prostaglandin E2 is cytoprotective and do not support the view that anticholinergics or histamin H2-receptor antagonists have a cytoprotective role on the cells of the gastric mucosa.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1980-11-01 | European Journal of Pharmacology |