6533b824fe1ef96bd1280afa
RESEARCH PRODUCT
A Promising Family of Fluorescent Water-Soluble aza-BODIPY Dyes for in Vivo Molecular Imaging.
Jacques PliquettJacques PliquettNesrine MabroukNesrine MabroukAdrien DuboisCindy RacoeurCindy RacoeurEwen BodioClaire BernhardFranck DenatPierre Simon BellayeChristine GozeSouheila AmorCatherine PaulCatherine PaulBertrand CollinAli BettaiebAli BettaiebRobin Lescuresubject
Boron CompoundsBiomedical EngineeringPharmaceutical ScienceQuantum yieldBioengineering02 engineering and technology01 natural sciencesMiceIn vivoCell Line TumorAza-bodipyAnimalsHumansFluorescent DyesPharmacologyMice Inbred BALB C010405 organic chemistryChemistryOrganic ChemistryWater021001 nanoscience & nanotechnologyCombinatorial chemistryFluorescenceIn vitro0104 chemical sciences3. Good healthMolecular ImagingWater solubleSolubilitySurface modificationHeterograftsMolecular imaging0210 nano-technologyBiotechnologydescription
A new family of water-soluble and bioconjugatable aza-BODIPY fluorophores was designed and synthesized using a boron- functionalization strategy. These dissymmetric bis-ammonium aza-BODIPY dyes present optimal properties for a fluorescent probe; i.e., they are highly water-soluble, very stable in physiological medium; they do not aggregate in PBS, possess high quantum yield; and finally, they can be easily bioconjugated to antibodies. Preliminary in vitro and in vivo studies were performed for one of these fluorophores to image PD-L1 (Programmed Death-Ligand 1), highlighting the high potential of these new probes for future in vivo optical imaging studies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-08 | Bioconjugate chemistry |