6533b824fe1ef96bd1281611
RESEARCH PRODUCT
Large clostridial cytotoxins — a family of glycosyltransferases modifying small GTP-binding proteins
Markus SauerbornChristoph Von Eichel-streiberMonica ThelestamPatrice Boquetsubject
ClostridiumMicrobiology (medical)Clostridium speciesMicrobial toxinsCytotoxinsBacterial ToxinsCellGlycosyltransferasesProtein superfamilyBiologyGlycosyltransferase activityMicrobiologyInfectious DiseasesGTP-binding protein regulatorsmedicine.anatomical_structureBiochemistryVirologyGlycosyltransferaseras Proteinsbiology.proteinmedicineCytotoxicitydescription
Some Clostridium species produce AB x -type protein cytotoxins of high molecular weight. These toxins constitute the group of large clostridial cytotoxins (LCTs), which have homologous protein sequences, exert glycosyltransferase activity and modify GTP-binding proteins of the Ras-superfamily. These characteristics render the LCTs valuable tools for developmental and cell biologists.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-10-01 | Trends in Microbiology |