An overview on anti-tubulin agents for the treatment of lymphoma patients

6533b824fe1ef96bd12816ed

RESEARCH PRODUCT

An overview on anti-tubulin agents for the treatment of lymphoma patients

Paola Barraja Anastasios Stathis Francesco Bertoni Marilia Barreca

subject

0301 basic medicine Vinca alkaloids Lymphoma Mitosis Antineoplastic Agents Apoptosis macromolecular substances Microtubules Antibody drug conjugates Taxanes 03 medical and health sciences 0302 clinical medicine Tubulin Microtubule medicine Animals Humans Maytansine Pharmacology (medical)Metaphase Mitosis Anaphase Pharmacology biology business.industry Cancer Combination chemotherapy medicine.disease Tubulin Modulators Lymphoma 030104 developmental biology Tubulin Epothilones 030220 oncology & carcinogenesis biology.protein Cancer research Dolastatins business

description

Anti-tubulin agents constitute a large class of compounds with broad activity both in solid tumors and hematologic malignancies, due to the interference with microtubule dynamics. Since microtubules play crucial roles in the regulation of the mitotic spindles, the interference with their function usually leads to a block in cell division with arrest at the metaphase/anaphase junction of mitosis, followed to apoptosis. This explains the reason why tubulin-binding agents (TBAs) proved to be extremely active in patients with cancer. Several anti-tubulin agents are indicated in the treatment of patients with lymphomas both alone and in combination chemotherapy regimens. The article reviews the literature on classic and more recent anti-tubulin agents, providing an insight into their mechanisms of action and their use in the treatment of lymphoma.

year	journal	country	edition	language
2020-03-11	Pharmacology & Therapeutics

https://doi.org/10.1016/j.pharmthera.2020.107552

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