6533b825fe1ef96bd1281d2f

RESEARCH PRODUCT

Determination of Phenylephrine Hydrochloride by Flow Injection Analysis with Chemiluminescence Detection

Luis Lahuerta ZamoraJosé Martínez CalatayudYolanda Fuster Mestre

subject

PharmacologyFlow injection analysisChromatographyChemistryCalibration curveAnalytical chemistryPhenylephrine HydrochlorideDosage formAnalytical Chemistrylaw.inventionPotassium permanganatechemistry.chemical_compoundlawmedicineEnvironmental ChemistryAgronomy and Crop SciencePhenylephrineQuantitative analysis (chemistry)Food Sciencemedicine.drugChemiluminescence

description

Abstract A new method is proposed for the determination of phenylephrine hydrochloride by flow injection analysis with direct chemiluminescence detection. The method is based on the oxidation of the drug by potassium permanganate in sulfuric acid medium at 80°C. The calibration graph is linear over the range 0.03–8 ppm phenylephrine hydrochloride, with a relative standard deviation (n = 51, 0.5 ppm) of 1.1% and sample throughput of 134/h. The influence of 38 different foreign compounds was tested, and the method was applied to the determination of phenylephrine hydrochloride in 8 different pharmaceutical formulations.

yearjournalcountryeditionlanguage
2001-01-01Journal of AOAC INTERNATIONAL
https://doi.org/10.1093/jaoac/84.1.13