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RESEARCH PRODUCT
Gas-phase ion chemistry of protonated melatonin
David BongiornoLorenzo CamardaMaurizio CiofaloVincenzo Turco LiveriSerena IndelicatoLeopoldo CerauloAndrea MeleMirella Ferrugiasubject
IonsElectrospraySpectrometry Mass Electrospray IonizationChemistryElectrospray ionizationInorganic chemistryDeuterium Exchange MeasurementProtonationmelatonin ESI/MS ESI/MS/MSion chemistryGeneral MedicineFast atom bombardmentPhotochemistryAtomic and Molecular Physics and OpticsIonFragmentation (mass spectrometry)AmmoniaTandem Mass SpectrometryAcetamidesProton affinityQuantum TheoryGasesProtonsSpectroscopyGas-phase ion chemistryMelatonindescription
The gas-phase ion chemistry of protonated melatonin has been investigated by mass spectrometric (MS) techniques involving chemical ionisation, fast atom bombardment and electrospray ionisation. Either naturally-occurring or collision-induced decomposition experiments have been carried out using side chain tetra-deuterium-labelled derivatives, as well as the corresponding N–D derivatives obtained by exchange with D2O. The analysis of experimental results allows definite pathways for the formation of the ion at m/z 174 to be assigned and sheds some more light on the overall fragmentation pathways. Experiments on labelled derivatives evidenced H–D scrambling processes during fragmentation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-01 |