Analysis of Epitope Spreading over an Eleven-year Period in a Patient with Systemic Lupus Erythematosus: CASE REPORT

6533b825fe1ef96bd128273c

RESEARCH PRODUCT

Analysis of Epitope Spreading over an Eleven-year Period in a Patient with Systemic Lupus Erythematosus: CASE REPORT

Helmut Deister Werner-johannes Mayet Marc Schmitz Sooghee Chang T Orth Michael Bachmann

subject

Systemic disease Lupus erythematosus Anti-nuclear antibody biology business.industry Immunology General Medicine medicine.disease medicine.disease_cause Epitope Autoimmunity Epitope mapping Rheumatology Antigen Immunology medicine biology.protein Immunology and Allergy Antibody skin and connective tissue diseases business

description

During a period of more than eleven years serum samples of a patient with Systemic Lupus Erythematosus were collected and analyzed for anti-nuclear autoantibodies. High titer of anti-La/SS-B were detectable in all serum samples. The La/SS-B epitopes remained constant. Besides anti-La/SS-B antibodies all serum samples contained traces of anti-Ro/SS-A including anti-Ro52 and anti-Ro60 antibodies. During disease flares anti-Ro/SS A antibodies were upregulated and anti-dsDNA antibodies appeared, thus supporting the concept of an antigen driven intermolecular epitope spreading to Ro/SS-A and dsDNA.

year	journal	country	edition	language
1998-01-01	Scandinavian Journal of Rheumatology

https://doi.org/10.1080/030097498442316

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