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RESEARCH PRODUCT

Frequency and clinical aspects of neurological and psychiatric symptoms in patients with non-celiac wheat sensitivity

Marta ChiavettaAlessandra GiulianoFrancesca FayerStella CompagnoniAda Maria FlorenaFrancesco La BlascaAurelio SeiditaAntonio CarroccioPasquale MansuetoAndrea AffrontiMaurizio SoresiDaniele CastellucciFrancesca Mandreucci

subject

0301 basic medicineduodenal lymphocytosisAdultMalemedicine.medical_specialtyLymphocytosisnon-celiac wheat sensitivityDiseaseWheat HypersensitivityGastroenterologyArticleDuodenal lymphocytosis HLA Irritable bowel syndrome Multiple food hypersensitivity Neuropsychiatric symptoms Non-celiac wheat sensitivity Adult Celiac Disease Female Humans Irritable Bowel Syndrome Male Nervous System Diseases Wheat HypersensitivityIrritable Bowel Syndrome03 medical and health sciences0302 clinical medicineInternal medicinemedicineIngestionHumansIn patientTX341-641multiple food hypersensitivityIrritable bowel syndromeNutrition and Dieteticsbusiness.industryNutrition. Foods and food supplymedicine.diseaseWheat hypersensitivityHLACeliac Disease030104 developmental biologyDuodenal mucosa030211 gastroenterology & hepatologyneuropsychiatric symptomsFemalemedicine.symptomNervous System DiseasesbusinessClinical recordFood Science

description

Background: Non-Celiac Wheat Sensitivity (NCWS) is characterized by both intestinal and extra-intestinal symptoms. The study aims to investigate the frequency of neuropsychiatric manifestations in NCWS patients and identify their clinical and demographic characteristics. Methods: 278 clinical records of NCWS patients, diagnosed by a double-blind placebo-controlled wheat challenge between 2006 and 2020, were retrospectively revised. Fifty-two patients with Celiac Disease (CD) and 54 patients with Irritable Bowel Syndrome (IBS) served as controls. Results: 87% of the NCWS patients had an IBS-like clinical presentation. The NCWS group showed a longer duration of symptoms, a higher frequency of positive serum anti-nuclear antibodies than CD and IBS patients, and a higher frequency of DQ2/DQ8 haplotypes and duodenal mucosa lymphocytosis than IBS controls. In addition, 50% of NCWS patients showed neuropsychiatric manifestations, while lower percentages were observed in CD (25%) and IBS (28%) controls. Neuropsychiatric symptoms in NCWS were more frequently associated with the male sex, longer duration of symptoms, and IBS-diarrhea-like clinical presentation. Conclusions: Our data suggest that in patients with IBS-like symptoms and neuropsychiatric manifestations of unknown cause, it could be useful to investigate a correlation of these symptoms with wheat ingestion to identify NCWS patients with this ‘atypical’ manifestation.

yearjournalcountryeditionlanguage
2021-06-01
10.3390/nu13061971http://hdl.handle.net/10447/521605