6533b825fe1ef96bd1282a05

RESEARCH PRODUCT

Visceral adiposity index is associated with histological findings and high viral load in patients with chronic hepatitis C due to genotype 1.

Salvatore PettaAldo GalluzzoCarla GiordanoVito Di MarcoAntonio CraxìCalogero CammàMarco Calogero AmatoDaniela Cabibi

subject

AdultBlood GlucoseMalemedicine.medical_specialtyPathologyAlcohol DrinkingGenotypeInterferon alpha-2Intra-Abdominal FatGastroenterologyAntiviral AgentsBody Mass IndexPolyethylene GlycolsInsulin resistanceInternal medicineDiabetes mellitusmedicineHumansHepatologymedicine.diagnostic_testbusiness.industryCholesterol HDLInterferon-alphaAlanine TransaminaseHepatitis CHepatologyHepatitis C ChronicMiddle AgedViral Loadmedicine.diseaseRecombinant ProteinsFatty LiverDiabetes Mellitus Type 2Liver biopsyHypertensionRNA ViralFemaleSteatosisWaist CircumferencebusinessViral loadBody mass index

description

Metabolic factors have been associated with liver damage in patients with genotype 1 chronic hepatitis C (G1 CHC). We tested visceral adiposity index (VAI), a new marker of adipose dysfunction in G1 CHC, patients to assess its association with host and viral factors and its link to both histological findings and sustained virological response (SVR). Two hundred thirtysix consecutive G1 CHC patients were evaluated by way of liver biopsy and anthropometric and metabolic measurements, including insulin resistance (IR), homeostasis model assessment (HOMA), and VAI using waist circumference, body mass index, triglycerides, and highdensity lipoprotein cholesterol. All biopsies were scored by one pathologist for staging and grading and graded for steatosis, which was considered moderate to severe if � 30%. Multiple linear regression analysis revealed that VAI score was independently associated with higher HOMA score (P 5 0.009), log10 hepatitis C virus RNA levels (P 5 0.01), necroinflammatory activity (P 5 0.04), and steatosis (P 5 0.04). Multiple logistic regression analysis revealed that IR (OR 3.879, 95% CI 1.727-8.713, P 5 0.001), higher VAI score (OR 1.472, 95% CI 1.051-2.062, P 5 0.02), and fibrosis (OR 2.255, 95% CI 1.349-3.768, P 5 0.002) were linked to steatosis � 30%. Logistic regression analysis revealed that older age (OR 1.030, 95% CI 1.002-1.059, P 5 0.03), higher VAI score (OR 1.618, 95% CI 1.001-2.617, P 5 0.04), and fibrosis (OR 2.608, 95% CI 1.565-4.345, P < 0.001) were independently associated with moderate to severe necroinflammatory activity. No independent associations were found between VAI score and both fibrosis and SVR. Conclusion: In G1 CHC patients, higher VAI score is independently associated with both steatosis and necroinflammatory activity and has a direct correlation with viral load. (HEPATOLOGY 2010;52:1543-1552)

yearjournalcountryeditionlanguage
2010-08-28Hepatology (Baltimore, Md.)
10.1002/hep.23859https://pubmed.ncbi.nlm.nih.gov/20799355