6533b825fe1ef96bd128311b
RESEARCH PRODUCT
New potential bimodal imaging contrast agents based on DOTA-like and porphyrin macrocycles
Jean-michel BarbeAntoine EggenspillerClaude P. GrosAline NonatFranck Denatsubject
PharmacologyCoordination sphereStereochemistryOrganic ChemistryPharmaceutical ScienceContrast (music)BiochemistryPorphyrinCombinatorial chemistrychemistry.chemical_compoundchemistryDrug DiscoveryMolecular MedicineDOTAMoleculeBifunctional chelatordescription
A bifunctional chelator featuring (DO3A-AM)-Porphyrin units has been prepared. The high-field relaxivity of the Gd complex is similar to those of currently available contrast agents clearly showing that the first coordination sphere remains identical to the parent molecule [Gd(DO3A-AM)(H2O)], with one coordinated water molecule.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-01-01 | Med. Chem. Commun. |