6533b825fe1ef96bd12832ae
RESEARCH PRODUCT
Ultrastructural study of the retina in late infantile metachromatic leukodystrophy.
Hans H. GoebelJürgen BohlHedwig Busch-hettwersubject
Retinal Ganglion CellsPathologymedicine.medical_specialtyAutopsyBiologycomplex mixturesRetinaCellular and Molecular NeuroscienceRetinal DiseasesmedicineHumansRetinaBrainGeneral MedicineLeukodystrophy Metachromaticmedicine.diseaseeye diseasesSensory SystemsGanglionMajor duodenal papillaMetachromatic leukodystrophyOphthalmologymedicine.anatomical_structurePeripheral nervous systemChild PreschoolOptic nerveUltrastructureFemalesense organsLysosomesdescription
The autopsy of a 2-year-old girl revealed a clinically unrecognized metachromatic leukodystrophy (MLD) due to an aryl-sulfatase A deficiency, characteristically affecting the central and peripheral nervous system by demyelination and by accumulation of metachromatic material. The retina though reported clinically as normal, showed the same demyelinating process in the optic nerve including the papilla but an additional intraneuronal storage of MLD-typical lysosomal residual bodies in ganglion cell perikarya of the retina. Cells of the bipolar and photoreceptor layers as well as pigment epithelial cells were not affected by MLD-specific lysosomal storage. Thus, sulfatides seem to play a particular metabolic role in ganglion cells but not in other neuronal cells of the retina in MLD.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-01-01 | Ophthalmic research |