6533b826fe1ef96bd1283b41

RESEARCH PRODUCT

Serotonin transporter gene polymorphism (5-HTTLPR) and emotional response to auditory hallucinations in schizophrenia

Klaus-peter LeschJulio SanjuánEduardo J. AguilarMaría Dolores MoltóOlga RiveroC. NájeraRosa De FrutosJ.c. González

subject

Pharmacologymedicine.medical_specialtybiologyNeurogenesismedicine.diseaseReuptakePsychiatry and Mental healthchemistry.chemical_compoundEndocrinologychemistrySchizophrenia5-HTTLPRInternal medicinemedicinebiology.proteinPharmacology (medical)SerotoninCircadian rhythmNeurotransmitterNeuroscienceSerotonin transporter

description

The serotonin transporter (5-HTT) has a crucial function in the regulation of serotonin (5-HT) reuptake in presynaptic neurons. 5-HT is a major modulator of emotional behaviour and circadian rhythms. In addition to its neurotransmitter role, it is also an important regulator of morphogenetic activities during early brain development as well as during adult neurogenesis and plasticity (Murphy et al., 2001).

https://doi.org/10.1017/s1461145705005559