6533b826fe1ef96bd1283cc0
RESEARCH PRODUCT
microRNA Expression Profile in Single Hormone Receptor-Positive Breast Cancers is Mainly Dependent on HER2 Status—A Pilot Study
Maria LitwiniukElżbieta Senkus-konefkaJoanna PikielRafał PęksaBarbara RadeckaMichał KuncKatarzyna PogodaMichał BieńkowskiAleksandra ŁAckoAdam KretowskiMarta PopędaMagdalena NiemiraAnna SzalkowskaWojciech BiernatEwa Iżycka-świeszewskaMarcin BraunAnna J. ŻAczeksubject
0301 basic medicineendocrine systemmedicine.drug_classClinical BiochemistryEstrogen receptorBiologyArticleprogesterone receptor03 medical and health sciences0302 clinical medicineBreast cancerbreast cancerHER2Progesterone receptormedicineReceptorskin and connective tissue diseaseslcsh:R5-920microRNAMicroRNA Expression Profilemedicine.diseaseFold change030104 developmental biologyEstrogenHormone receptor030220 oncology & carcinogenesisbreast cancer; estrogen receptor; progesterone receptor; HER2; microRNACancer researchlcsh:Medicine (General)hormones hormone substitutes and hormone antagonistsestrogen receptordescription
Estrogen (ER) and progesterone (PgR) receptors and HER2 are crucial in the assessment of breast cancer specimens due to their prognostic and predictive significance. Single hormone receptor-positive breast cancers are less common and their clinical course is less favorable than ER(+)/PgR(+) tumors. Their molecular features, especially microRNA (miRNA) profiles, have not been investigated to date. Tumor specimens from 36 chemonaive breast cancer patients with known ER and PgR status (18 ER(+)/PgR(&minus
year | journal | country | edition | language |
---|---|---|---|---|
2020-08-20 | Diagnostics |