6533b826fe1ef96bd1283f49
RESEARCH PRODUCT
Clonal analysis of human T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis
Michael MannsKarl-hermann Meyer Zum BüschenfeldeThierry HercendGeorg HessHans Peter DienesStefan MeuerUlrich MoebiusGuiliano Ramadorisubject
CD4-Positive T-LymphocytesCytotoxicity ImmunologicPathologymedicine.medical_specialtyT-LymphocytesBiliary cirrhosisImmunologyChronic liver diseasePrimary biliary cirrhosismedicineHumansImmunology and AllergyCytotoxic T cellHepatitis Chronicmedicine.diagnostic_testLiver Cirrhosis Biliarybusiness.industryLiver cellHepatobiliary diseaseAntibodies MonoclonalT lymphocyteHepatitis Bmedicine.diseaseClone CellsKiller Cells NaturalLiver biopsyImmunologybusinessT-Lymphocytes Cytotoxicdescription
Human T lymphocytes infiltrating the liver in chronic active hepatitis B (CAH-B) and primary biliary cirrhosis were isolated from liver biopsy cores, cloned by limiting dilution technique and expanded in vitro. Phenotypic and functional analysis demonstrates that this tissue infiltrate represents a heterogeneous cell population. However, when compared to peripheral blood lymphocytes of the same patients, a marked enrichment for T8+ cytotoxic T cells was found to exist at a local site in both types of chronic liver disease. These data provide support for the notion that liver cell injury in CAH-B and PBC may be mediated by a common immunologic mechanism likely executed by cells of the T lineage.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1988-09-01 | European Journal of Immunology |