6533b826fe1ef96bd1284300
RESEARCH PRODUCT
Defective apoptosis as potential mechanism in the tumorogenesis of myelolipoma
Francesco CappelloFarina FDi Felice VMarcianò VTodaro MBalsano GZummo GStassi Gsubject
FaAdrenal Gland NeoplasmsAntigens Differentiation MyelomonocyticApoptosiApoptosisBone Marrow CellsCell BiologyChoristomaImmunohistochemistryApoptosis; Bone marrow; Choristoma; Fas; Myelolipoma; Cell Biology; Anatomy; Animal Science and Zoology; Developmental BiologyMyelolipomaAntigens CDIn Situ Nick-End LabelingHumansBone marrowAnimal Science and Zoologyfas ReceptorAnatomyDevelopmental Biologydescription
Apoptosis is considered an important mechanism of selective deletion that occurs during hematopoiesis. Myelolipoma is a rare benign tumor composed of adipose tissue and hematopoietic cells. The pathogenesis of this benign tumor is still unclear. Analysing the structural levels and apoptosis of normal human bone marrow (NHBM) and human myelolipoma (HM), the apoptotic events resulted abundantly present in NHBM compared to HM, which showed a small number of apoptotic cells. By contrast, Fas expression was strongly present both in NHBM and HM. These findings suggest that an altered function of Fas in myelolipoma is not able to trigger the apoptotic machinery. In conclusion, we hypothesize that drastic reduction of apoptosis in myelolipoma can be considered one of the growth regulatory mechanisms.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-05-26 |