6533b826fe1ef96bd128465a

RESEARCH PRODUCT

Bioactive saponins from plants: An update

Marie-aleth Lacaille-duboisH. Wagner

subject

Antifungalchemistry.chemical_classificationBroad spectrumchemistryTriterpenemedicine.drug_classmedicine.medical_treatmentmedicineGlycosidePharmacologyBiologyImmunoadjuvantSteroid

description

Plant saponins are a group of naturally occuring triterpene or steroid glycosides which include a large number of biologically and pharmacologically active compounds. Saponins have been shown in both in vitroand in vivoexperimental test systems during the last decade to possess a broad spectrum of biological and pharmacological activities. This review will summarize some of the recent advances concerning cancer-related activity, immunostimulating, immunoadjuvant, antihepatotoxic, antiphlogistic, antiallergic, molluscicidal, hemolytic, antifungal, antiviral, and hypoglycemic activities. In addition, the effects on the cardiovascular system and the central nervous system will be discussed together with other miscellaneous effects. Studies of structure/activity relationships and mechanism of action will be presented.

https://doi.org/10.1016/s1572-5995(00)80015-0