6533b826fe1ef96bd12850be

RESEARCH PRODUCT

Prolonged anaesthesia with isoflurane and halothane. Effects on hepatic function.

W. F. DickP. P. KleemannA. KleinP. K. WittonF. MertzlufftJan-peter A. H. Jantzen

subject

Time FactorsBilirubinHepatic functionchemistry.chemical_compoundmedicineHumansProthrombin timebiologymedicine.diagnostic_testFactor VIIIsofluranebusiness.industryFactor VFactor VBilirubinFactor VIIAnesthesiology and Pain MedicinechemistryIsofluraneLiverAnesthesiabiology.proteinProthrombin TimeLiver functionHalothanebusinessAnesthesia InhalationHalothanemedicine.drug

description

Hepatic function was assessed pre-operatively and on the first and sixth postoperative days in 40 healthy patients who underwent prolonged maxillofacial surgery with isoflurane or halothane anaesthesia. No major changes were observed in hepatic enzymes or bilirubin. One-stage prothrombin time and Factor VII concentrations decreased on the first postoperative day and this change was more pronounced in the halothane group. The results support the use of isoflurane rather than halothane for prolonged anaesthesia in respect of the synthesising function of the liver.

yearjournalcountryeditionlanguage
2007-02-22Anaesthesia
10.1111/j.1365-2044.1988.tb05536.xhttps://pubmed.ncbi.nlm.nih.gov/3364635