6533b826fe1ef96bd1285101

RESEARCH PRODUCT

Immune profiling of Alzheimer patients

Calogero CarusoGraham PawelecDavid GoldeckAnis LarbiGiuseppina Colonna-romanoSilvio BuffaMatteo BulatiGraziella RubinoEvelyna DerhovanessianFrancesco IemoloGiuseppina CandoreMariavaleria Pellicanò

subject

AdultCD4-Positive T-LymphocytesMaleImmunosenescenceT cellImmunologyStimulationDiseaseCD8-Positive T-LymphocytesBiologyYoung AdultAlzheimer DiseaseExtracellularmedicineHumansImmunology and AllergySenile plaquesAgedAged 80 and overSettore MED/04 - Patologia GeneraleGene Expression ProfilingAβ42Age FactorsT cellCell DifferentiationImmunosenescenceMiddle AgedAlzheimer's diseasePhenotypeCD4 Lymphocyte Countmedicine.anatomical_structureNeurologyImmunologyEtiologyFemaleNeurology (clinical)Biomarkers

description

Abstract Alzheimer's disease (AD) is characterized by extracellular senile plaques in the brain, containing amyloid-β peptide (Aβ). We identify immunological differences between AD patients and age-matched controls greater than those related to age itself. The biggest differences were in the CD4 + rather than the CD8 + T cell compartment resulting in lower proportions of naive cells, more late-differentiated cells and higher percentages of activated CD4 + CD25 + T cells without a Treg phenotype in AD patients. Changes to CD4 + cells might be the result of chronic stimulation by Aβ present in the blood. These findings have implications for diagnosis and understanding the aetiology of the disease.

yearjournalcountryeditionlanguage
2011-09-12Journal of Neuroimmunology
https://doi.org/10.1016/j.jneuroim.2011.11.005