6533b826fe1ef96bd1285357

RESEARCH PRODUCT

Alcoholic beverages, obesity, physical activity and other nutritional factors, and cancer risk: A review of the evidence

Julie Le MerdyFabrice PierreVanessa CottetNathalie Druesne-pecolloMarina TouillaudR. AncellinMathilde TouvierMarie-paule VassonPaule Latino-martelEmilie BarrandonMélanie Deschasaux

subject

[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/HematologyGastric cardia adenocarcinomaBreastfeedingReviewOverweightDose-response metaanalysis[ SDV.CAN ] Life Sciences [q-bio]/Cancer0302 clinical medicineNeoplasmsPrimary liver-cancerBeta-carotene supplementsBody-mass Index[ SDV.MHEP.HEM ] Life Sciences [q-bio]/Human health and pathology/HematologyCruciferous vegetables intakeDeveloping lung-cancer030212 general & internal medicineCancer2. Zero hungerProcessed meat consumptionAlcoholic Beverages[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/HematologyHematologyRenal-cell cancer3. Good healthOncology030220 oncology & carcinogenesisRandomized controlled-trialsRed meatmedicine.symptomAlcoholAlcohol;Beta-carotene supplements;Breastfeeding;Cancer;Diet;Obesity;Physical activity;PreventionBreastfeeding[SDV.CAN]Life Sciences [q-bio]/CancerMotor Activity03 medical and health sciences[SDV.CAN] Life Sciences [q-bio]/CancerEnvironmental healthmedicineHumansObesityExerciseCancer preventionbusiness.industryPhysical activityPreventionCancerEvidence-based medicinemedicine.diseaseObesityBeta-carotene supplementationBiotechnologyDietGeriatrics and GerontologybusinessBody mass index

description

International audience; Purpose: Prevention is a priority in the fight against cancers, especially nutritional prevention. To update the levels of evidence of relationships between 10 nutritional factors and cancer risk, the scientific literature published from 2006 to 2014 was reviewed by an expert group.Methods: Data from 133 meta-analyses, pooled analyses or intervention trials were examined. Nearly 150 relationships between nutritional factors and cancer at various sites were evaluated.Results: According to the evidence graded as convincing or probable, these factors were divided in two groups. Factors which increase the risk of cancer are alcoholic beverages, overweight and obesity, red meat and processed meat, salt and salted foods and beta-carotene supplements. Factors which decrease the risk of cancer are physical activity, fruits and vegetables, dietary fiber, dairy products and breastfeeding.Conclusion: Three main nutritional objectives should be attained to improve cancer prevention: to reduce alcoholic beverages consumption, to have a balanced and diversified diet and to be physically active. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.

10.1016/j.critrevonc.2016.01.002http://dx.doi.org/10.1016/j.critrevonc.2016.01.002