Forever Young: Structural Stability of Telomeric Guanine Quadruplexes in the Presence of Oxidative DNA Lesions**

6533b826fe1ef96bd12853bb

RESEARCH PRODUCT

Forever Young: Structural Stability of Telomeric Guanine Quadruplexes in the Presence of Oxidative DNA Lesions**

Camille Corbier Stéphanie Grandemange Tom Miclot Tom Miclot Cécilia Hognon Alessio Terenzi Antonio Monari Giampaolo Barone

subject

Circular dichroism Telomerase Oxidative phosphorylation 010402 general chemistry Immunofluorescence medicine.disease_cause 01 natural sciences electronic circular dichroism Catalysis [SPI.AUTO]Engineering Sciences [physics]/Automatic chemistry.chemical_compound medicine Humans immunofluorescence Telomerase chemistry.chemical_classification medicine.diagnostic_test 010405 organic chemistry Circular Dichroism Organic Chemistry DNA General Chemistry Telomere molecular dynamics 0104 chemical sciences 3. Good health G-Quadruplexes Oxidative Stress Enzyme Biochemistry chemistry Settore CHIM/03 - Chimica Generale E Inorganica Guanine quadruplexes Nucleic Acid Conformation oxidative DNA lesions Guanine-Quadruplexes DNA Oxidative stress

description

International audience; Human telomeric DNA, in G-quadruplex (G4) conformation, is characterized by a remarkable structural stability that confers it the capacity to resist to oxidative stress producing one or even clustered 8-oxoguanine (8oxoG) lesions. We present a combined experimental/computational investigation, by using circular dichroism in aqueous solutions, cellular immunofluorescence assays and molecular dynamics simulations, that identifies the crucial role of the stability of G4s to oxidative lesions, related also to their biological role as inhibitors of telomerase, an enzyme overexpressed in most cancers associated to oxidative stress.

year	journal	country	edition	language
2021-06-16

10.1002/chem.202100993 http://hdl.handle.net/10447/513790

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