6533b827fe1ef96bd12859ba

RESEARCH PRODUCT

ADIPOKINES IN CHILDREN WITH CHRONIC RENAL FAILURE

Maria Cristina Maggio

subject

medicine.medical_specialtyAdiponectinbusiness.industryLeptinAdipokineAnorexiamedicine.diseaseEndocrinologyInsulin resistanceInternal medicinemedicineResistinmedicine.symptombusinessWastinghormones hormone substitutes and hormone antagonistsHomeostasis

description

Chronic Renal Failure (CRF) has negative impact on nutrition, growth, puberty, glycometabolic homeostasis, adipokines secretion. Adipokines play a role on these patients' short term complications and they influence their long term outcome. Many studies highlighted the influence of adipokines on cardiovascular complications, glycometabolic assess, nutrition of adults and children with CRF. High serum resistin and adiponectin levels can have a possible role in the development of protein-energy wasting among CRF patients. Elevated serum leptin levels were thought to contribute to the anorexia and poor nutrition in children on haemodialysis for CRF. Several studies have demonstrated leptin influence on growth and puberty, resistin role on glycaemic profile and insulin resistance, the meaning of adiponectin as an anti-inflammatory and antiatherogenic factor.

yearjournalcountryeditionlanguage
2015-05-02Immunoendocrinology
https://doi.org/10.14800/ie.456