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RESEARCH PRODUCT

Increased sirtuin expression in patient with lung squamous cell carcinoma co-morbid with COPD

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Background: COPD is frequently associated with comorbidities, the most serious and prevalent include lung cancer. Sirtuin 1 (SIRT1) is known to deacetylate histones and non-histone proteins including transcription factors thereby regulating metabolism, stress resistance, cellular survival, cellular senescence/aging. The aim of our study was to evaluate SIRT-1 expression in patients with lung squamous cell carcinoma and adenocarcinoma and these co-morbid with COPD. Methods: 93 patients with lung nonsmall cell lung carcinoma co-morbid with moderate severity COPD (n=29) or without COPD were enrolled in the study. Lung function testing was performed within one week before lung surgery. SIRT-1 expression in cancer tissue was compared to control tissue (obtained from 15 autopsy cases) and analyzed by immunohistochemistry. Results: Obtained results showed that in patients co-morbid with COPD and lung cancer, the SIRT-1 expression was higher in squamous cell carcinoma compared to patients without COPD (88 ± 26 vs. 42 ± 18 cell/ mm2; p=0.01). At the same time the SIRT-1 expression did not differ in adenocarcinoma and COPD co-morbidity specimens compared to those without COPD. Conclusion: Patients with lung squamous cell carcinoma co-morbid with COPD have increased SIRT-1 expression if compared to carcinoma patients without COPD.