6533b827fe1ef96bd1285c51

RESEARCH PRODUCT

Anidulafungin in combination with amphotericin B against Aspergillus fumigatus.

Giorgio ScaliseElisabetta SpreghiniMaria Eleonara MiliciCristian LoretelliAlfredo SantinelliFiorenza OrlandoEsther MansoEleonora PisaFrancesco Barchiesi

subject

Settore MED/07 - Microbiologia E Microbiologia ClinicaAntifungal AgentsCombination therapymedicine.drug_classAntibioticsMicrobial Sensitivity TestsPharmacologyAspergillosisAnidulafunginKidneyAspergillus fumigatusMicrobiologyEchinocandinsMicePharmacotherapyAmphotericin BAmphotericin BmedicineAnimalsAspergillosisPharmacology (medical)Experimental TherapeuticsPharmacologyAspergillusbiologyAspergillus fumigatusaspergillus anidulafungin amphotericin BBrainbiology.organism_classificationmedicine.diseasebacterial infections and mycosesInfectious DiseasesAnidulafunginDrug Therapy Combinationmedicine.drug

description

ABSTRACT We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus . Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug.

yearjournalcountryeditionlanguage
2009-07-15Antimicrobial agents and chemotherapy
10.1128/aac.00659-09https://pubmed.ncbi.nlm.nih.gov/19596890