6533b827fe1ef96bd1285d7c
RESEARCH PRODUCT
The evolution and changing ecology of the African hominid oral microbiome
Ana Grande MateuCourtney A. HofmanKaterina HarvatiLouise T. HumphreyMario MenéndezRichard W. WranghamDušan MihailovićKathryn Weedman ArthurCody ParkerCody ParkerBarbara TeßmannJay T. StockJay T. StockJay T. StockIsabelle CrevecoeurMichael J. WalkerCatherine C. BauerChristina WarinnerChristina WarinnerChristina WarinnerCosimo PosthCosimo PosthMirjana RoksandicVictoria E. GibbonLove DalénDorothée G. DruckerAmanda G. HenryManuel R. González MoralesFloyd E. DewhirstFloyd E. DewhirstKathrin NägeleChristophe CupillardMichael FranckenIrina M. VelskoJohannes KrauseSofía Rodríguez MoroderSandra SázelováKaterina GuschanskiKaterina GuschanskiKaterina GuschanskiRita M. AustinRita M. AustinJames A. Fellows YatesJames A. Fellows YatesJ. Carlos Díez Fernández-lomanaMarta Díaz-zorita BonillaHélène RougierCecil M. LewisMarco PeresaniMarco PeresaniRobert C. PowerRobert C. PowerKrithivasan SankaranarayananDomingo C. Salazar-garcíaLawrence Guy StrausAlexander HerbigJiří SvobodaJiří SvobodaJohn W. ArthurElena Escribano EscriváMatthew C. CurtisFranziska AronAllison E. Mannsubject
Neanderthalbindinggut microbiomemicrobiomeprimatePrehistòriaNeanderthalEvolutionsbiologiPrimatesalivary amylasePhylogeny0303 health sciencesMultidisciplinaryEcologyGeographybiologyEcologyMicrobiotaHuman microbiomeancientHominidae402SH6_2Biological SciencesBiological Evolutiongenomes suggestHuman evolution[SDE]Environmental SciencesOral MicrobiomeR-packagePan troglodytesdental plaque[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and PrehistoryEcology (disciplines)Socio-culturaleMicrobiologysalivary alpha-amylase03 medical and health sciencesbiology.animalDental calculus; microbiome; Neanderthal; primate; salivary amylaseAnimalsHumansMicrobiomevisualization030304 developmental biologyMouthperiodontal-diseaseEvolutionary BiologyGorilla gorillaBacteria030306 microbiologydental calculusDNAMikrobiologiBiofilmsFOS: Biological sciencesAnthropologyAfricaUpper PaleolithicMetagenomedescription
Significance The microbiome plays key roles in human health, but little is known about its evolution. We investigate the evolutionary history of the African hominid oral microbiome by analyzing dental biofilms of humans and Neanderthals spanning the past 100,000 years and comparing them with those of chimpanzees, gorillas, and howler monkeys. We identify 10 core bacterial genera that have been maintained within the human lineage and play key biofilm structural roles. However, many remain understudied and unnamed. We find major taxonomic and functional differences between the oral microbiomes of Homo and chimpanzees but a high degree of similarity between Neanderthals and modern humans, including an apparent Homo-specific acquisition of starch digestion capability in oral streptococci, suggesting microbial coadaptation with host diet.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-05-10 |