6533b827fe1ef96bd1285de9

RESEARCH PRODUCT

Safety of etanercept therapy in rheumatoid patients undergoing surgery: preliminary report

Corrao SalvatoreGiovanni PistoneGiuseppe LicataS. ArnoneRosario ScaglioneLuigi Calvo

subject

AdultMalemusculoskeletal diseasesmedicine.medical_specialtySettore MED/09 - Medicina InternaPilot ProjectsReceptors Tumor Necrosis FactorEtanerceptEtanerceptArthritis RheumatoidPostoperative ComplicationsPatient satisfactionRheumatologyInternal medicinemedicineHumansPostoperative PeriodElective surgeryWound Healingmedicine.diagnostic_testTumor Necrosis Factor-alphabusiness.industryContraindicationsGeneral MedicineCystoscopyMiddle Agedmedicine.diseaseRheumatologySurgerySettore MED/16 - ReumatologiaTolerabilityElective Surgical ProceduresImmunoglobulin GRheumatoid arthritisFemaleBiological therapy Decompensated diabetes mellitus Etanercept Polymyalgia rheumatica Steroid therapy.businessAdverse drug reactionmedicine.drug

description

This is a preliminary report on a case-series of rheumatoid patients that underwent various kinds of elective surgery but did not withdraw etanercept therapy in spite of physician advise. Elective surgery consisted of right knee surgical prosthesis, bilateral cataract, bilateral hallux valgus, right hip prosthesis, bladder stone by cystoscopy and left inguinal hernia. All the patients had a regular healing rate. During follow-up (6-12 months) no one of these patients were suffering from infective complications after surgery. According to same recent literature results, our data suggest that it is the time to value rheumatoid patient preferences through a correct information about cost-benefit of this treatment to establish together with patients if etanercept therapy has to be discontinued before and after elective surgery. Finally, we think that adverse drug reaction surveillance has to be boosted, and editors of leading scientific journal should publish more papers on case-series about drug safety and tolerability in particular conditions.

yearjournalcountryeditionlanguage
2009-01-01Clinical Rheumatology
https://doi.org/10.1007/s10067-007-0534-0