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RESEARCH PRODUCT
Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties
Nicolas SpinelliMuriel JourdanThibaut ConstantinSylvain PenasseMarc PirrottaAurélien LaguerreJérôme DejeuDavid MonchaudEric DefrancqBéatrice GennaroTheodore Flacksubject
0301 basic medicineModels MolecularGuanineStereochemistryDNAzymewaterSupramolecular chemistryDeoxyribozymednainsights010402 general chemistryG-QuartetsG-quadruplexchemistry[ CHIM ] Chemical Sciences01 natural sciencesCatalysissupramolecular chemistryg-quadruplex structures03 medical and health scienceschemistry.chemical_compoundG-quartets[CHIM]Chemical SciencesrnaComputingMilieux_MISCELLANEOUSligandsbiologyOrganic Chemistry[CHIM.CATA]Chemical Sciences/CatalysisGeneral ChemistryDNA CatalyticSmall moleculeG-quadruplexes0104 chemical sciencesSolutionssmall molecules030104 developmental biologychemistryBiocatalysisIntramolecular forceBiocatalysisNucleic Acid Conformationcyclodecapeptideaciddescription
International audience; A water-soluble template-assembled synthetic G-quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase-type biocatalytic activities and improved quadruplex-interacting properties. Comparison of its DNAzyme-boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme-boosting agent.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-26 |