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RESEARCH PRODUCT
EFFECTS OF DIETARY 18:3 N-3 TRANS ISOMERS ON THE ?6 DESATURATION OF ?-LINOLENIC ACID
Jean-louis SébédioAndré GrandgirardJp BlondJean-michel Chardignysubject
chemistry.chemical_classificationRat liver microsomesChemistryStereochemistryMicrosomeGeneral ChemistryLong chainCis–trans isomerismFood Scienceα-linolenic acidPolyunsaturated fatty aciddescription
Trans isomers of polyunsaturated fatty acids (PUFA) are formed during heat treatment of oils. In the present work, the effect of dietary geometrical isomers of α-linolenic acid (18:3 n-3) on the Δ6 desaturation of all cis 18:3 n-3 was investigated, using rat liver microsomes. The desaturation rates were higher in microsomes from animals fed a cis n-3 deficient diet, as compared to those from the control group or those from rats fed 18:3 n-3 and its trans isomers. These data and the incorporation of long chain trans PUFA in microsomal lipids suggest that geometrical isomers of 18:3 n-3 are probably slowly desaturated and elongated into long chain trans polyunsaturated fatty acids compared to 18:3 n-3.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-06-01 | Journal of Food Lipids |