6533b827fe1ef96bd1286fd9

RESEARCH PRODUCT

Clinicopathological and Immunohistochemical Study of Oral Amalgam Pigmentation

Beatriz Vera-sireraJosé M. Ricart-vayáPresentación Risueño-mataFrancisco Vera-sempereCarmen Baquero Ruíz De La Hermosa

subject

MalePathologymedicine.medical_specialtyStromal cellBiopsyGingivaAntigens Differentiation MyelomonocyticHLA-DR alpha-ChainsDental AmalgamMelanosisDiagnosis DifferentialPhagocytosisAntigens CDMetals HeavyBiopsymedicineHumansMast CellsPigmentation disorderGranulomabiologymedicine.diagnostic_testCD117business.industryForeign-Body ReactionMacrophagesAmalgam tattooMouth MucosaGeneral MedicineBuccal administrationMiddle Agedmedicine.diseaseMelanosisCorrosionProto-Oncogene Proteins c-kitstomatognathic diseasesGranulomabiology.proteinFemaleMetallothioneinMicroscopy PolarizationbusinessPigmentation Disorders

description

Amalgam tattoo, the most common exogenous oral pigmentation, can sometimes be confused with melanotic lesions, being then biopsied. We present the clinicopathological characteristics of 6 biopsied cases (5 females and 1 male) of oral amalgam pigmentation. The most common location was the gingival mucosa, followed by the buccal and palatal mucosa. Morphology and distribution (stromal, perivascular, perineural, endomysial) of pigmentation was variable; there was only 1 case with fibrous capsular reaction and likewise only a single case of granulomatous foreign body reaction. Morphological variability is conditioned by the timing and amount of the pigment deposit, which is often associated with infiltration by mast cells (CD117+), as well as overexpression of metallothionein and HLA-DR at different tissue levels.

yearjournalcountryeditionlanguage
2012-09-01Acta Otorrinolaringologica (English Edition)
https://doi.org/10.1016/j.otoeng.2012.09.006