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RESEARCH PRODUCT
Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant.
Barbara BottazziCecilia GarlandaAlberto MantovaniGiuseppe MancusoSilvana SavinoGiuseppe TetiMarina SironiAna I. DíezMarzia Monica GiulianiConcetta BeninatiLivija DebanMariagrazia PizzaRino RappuoliLaura SantiniSonia Valentinosubject
MaleOvalbuminGene Expressionlcsh:MedicineMeningococcal VaccinesMeningococcal vaccineMeningitis MeningococcalNeisseria meningitidismedicine.disease_causeMicrobiologyMice03 medical and health sciencesImmune systemAdjuvants ImmunologicAntigenImmunitymedicineAnimalsRats Wistarlcsh:Science030304 developmental biologyMice KnockoutAntigens Bacterial0303 health sciencesNeisseria meningitidis PTX3 vaccination protocolsMultidisciplinarybiology030306 microbiologyNeisseria meningitidisVaccinationlcsh:RPTX3Antibodies BacterialVirologyBacterial LoadImmunity InnateImmunity HumoralRats3. Good healthSerum Amyloid P-ComponentC-Reactive ProteinAnimals Newbornbiology.proteinFemalelcsh:QAntibodyBacterial outer membraneResearch Articledescription
Long pentraxin 3 (PTX3) is a non-redundant component of the humoral arm of innate immunity. The present study was designed to investigate the interaction of PTX3 with Neisseria meningitidis. PTX3 bound acapsular meningococcus, Neisseria-derived outer membrane vesicles (OMV) and 3 selected meningococcal antigens (GNA0667, GNA1030 and GNA2091). PTX3-recognized microbial moieties are conserved structures which fulfil essential microbial functions. Ptx3-deficient mice had a lower antibody response in vaccination protocols with OMV and co-administration of PTX3 increased the antibody response, particularly in Ptx3-deficient mice. Administration of PTX3 reduced the bacterial load in infant rats challenged with Neisseria meningitidis. These results suggest that PTX3 recognizes a set of conserved structures from Neisseria meningitidis and acts as an amplifier/endogenous adjuvant of responses to this bacterium.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 | PLoS ONE |