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RESEARCH PRODUCT
Paraneoplastic Focal Outer Retinitis and Optic Neuropathy in a Patient with Small Cell Lung Carcinoma and Anti-CRMP5, Anti-HU and Anti-Amphiphysin Antibodies
Alex FonollosaJoseba ArtarazInazio LacambraClara Martínez-rubioLena Giraltsubject
Pathologymedicine.medical_specialtyAtaxiagenetic structuresmedicine.medical_treatmentRetinitisCase ReportMalignancy01 natural sciencesOptic neuropathy03 medical and health scienceschemistry.chemical_compound0302 clinical medicineAtrophylcsh:Ophthalmologymedicine0101 mathematicsOptic disc oedemabusiness.industry010102 general mathematicsRetinitisRetinalmedicine.diseaseCollapsin response mediator protein 5eye diseasesRadiation therapyOphthalmologychemistrylcsh:RE1-994030221 ophthalmology & optometryParaneoplastic syndromeAtaxiaSmall Cell Lung Carcinomasense organsmedicine.symptombusinessdescription
Our aim is to describe clinical and optical coherence tomographic features of acute paraneoplastic focal outer retinitis associated with optic neuropathy in a patient diagnosed with small cell lung carcinoma. Bilateral focal outer retinitis, bilateral optic disc oedema and vitritis were identified in a patient with progressive bilateral visual loss and ataxia. Spectral domain optical coherence tomography (SD-OCT) revealed various extents of granular hyperreflectivity and atrophy of the macular outer retinal layers. Serum and cerebrospinal fluid positivity for anti-CRMP5, anti-HU and anti-amphiphysin antibodies intensified the search for an underlying malignancy, and a small cell lung carcinoma (SCLC) was finally diagnosed. Local and oral steroids along with systemic chemotherapy and radiotherapy achieved cancer remission and partial recovery from the ophthalmic manifestations. Focal outer retinitis associated with optic disc oedema and antibody positivity facilitated the diagnosis of SCLC in a localized stage. SD-OCT allowed the characterization of this entity, expanding the spectrum of paraneoplastic ophthalmological syndromes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-09-01 | Case Reports in Ophthalmology |