6533b828fe1ef96bd1287a0f
RESEARCH PRODUCT
CuCl catalyzed radical cyclisation of N-alpha-perchloroacyl-ketene-N,S-acetals: a new way to prepare disubstituted maleic anhydrides
Mariella PattarozziVincenzo FrennaAndrew F. ParsonsAndrea CorniaDomenico SpinelliFulvia FellugaFranco GhelfiFabrizio Roncagliasubject
S-acetals alpha-Perchloroenamides Copper(I) chloride 5-endo Radical cyclization Maleic anhydridesCyclic compoundOrganic ChemistryAcetalKeteneMethyl radicalMaleic anhydrideSettore CHIM/06 - Chimica OrganicaBiochemistryRadical cyclizationMedicinal chemistryCyclic ketene-N; S-acetals alpha-Perchloroenamides Copper(I) chloride 5-endo Radical cyclization Maleic anhydrideschemistry.chemical_compoundchemistryCyclic ketene-N; S-acetals; alpha-perchloroenamides; Copper(I)chloride; 5-endo radical cyclization; maleic anhydridesDrug DiscoveryCyclic ketene-NS-acetals a-perchloroenamides copper(I) chloride maleic anhydridesCyclic ketene-NImideMaleimidedescription
The discovery that cycloalkanes can form thermomorphic systems with typical polar organic solvents has led to the development of less-polar electrolyte solutions. Their mixing and separation can be regulated reversibly at a moderate temperature range. The phase switching temperature can be controlled by changing the solvent compositions. While biphasic conditions are maintained below the phase switching temperature, conductive monophasic conditions as less-polar electrolyte solutions are obtained above the phase switching temperature. After the electrochemical transformations, biphasic conditions are reconstructed below the phase switching temperature, facilitating the separation of cycloalkane where hydrophobic products or designed hydrophobic platforms are selectively partitioned. Several polar organic solvents, including acetonitrile, methanol, and pyridine, can be used in this system according to the requirement of the reactions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-07-01 |