6533b828fe1ef96bd1287b78

RESEARCH PRODUCT

A PDCD1 Role in the Genetic Predisposition to NAFLD-HCC?

Ann K. DalyAlastair BurtRebecca DarlayYang Lin LiuMarco Y W ZakiMarco Y W ZakiMoustafa FathyNikki Martina McstrawMisti Vanette MccainHelen L. ReevesHelen L. ReevesRobyn WatsonMichael Atef FawzyJean-françois DufourJean-françois DufourNardeen EldafashiNardeen EldafashiCristiana BiancoQuentin M. AnsteeQuentin M. AnsteeHeather J. CordellLuca ValentiRuchi ShuklaBeate HaugkJoão Maurício

subject

0301 basic medicineCancer ResearchCirrhosisprimary liver cancer<i>PDCD1</i>610 Medicine & healthDiseaseBioinformaticslcsh:RC254-282digestive systemArticleTM6SF2metabolic syndrome03 medical and health sciences0302 clinical medicinePD-1medicineGenetic predispositionPNPLA3business.industry<i>TM6SF2</i>PDCD1Fatty livernutritional and metabolic diseaseshepatocellular carcinomasingle-nucleotide polymorphismlcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseasedigestive system diseases3. Good health<i>PNPLA3</i>030104 developmental biologyOncology030211 gastroenterology & hepatologyMetabolic syndromeSteatohepatitisSteatosisbusinessgenetic predispositionTM6SF2

description

Obesity and non-alcoholic fatty liver disease (NAFLD) are contributing to the global rise in deaths from hepatocellular carcinoma (HCC). The pathogenesis of NAFLD-HCC is not well understood. The severity of hepatic steatosis, steatohepatitis and fibrosis are key pathogenic mechanisms, but animal studies suggest altered immune responses are also involved. Genetic studies have so far highlighted a major role of gene variants promoting fat deposition in the liver (PNPLA3 rs738409

yearjournalcountryeditionlanguage
2021-03-01Cancers
https://doi.org/10.3390/cancers13061412