6533b828fe1ef96bd1287b8d

RESEARCH PRODUCT

Spiral wave induced numerically using electrical stimulation and comparison with experimental results.

Sabir JacquirStéphane BinczakGabriel LaurentBinbin XuJean-marie Bilbault

subject

Materials scienceBiomedical EngineeringAction PotentialsStimulationAnimalsComputer SimulationElectrodesCells CulturedModels StatisticalComputer simulationMyocardiumModels CardiovascularArrhythmias CardiacHeartMultielectrode arrayMechanicsElectric StimulationRatsElectrophysiologyMicroelectrodeAnimals NewbornSpiral waveElectrodeCurrent (fluid)Spiral (railway)AlgorithmsBiomedical engineering

description

Experiments in vitro on a Microelectrode Array (MEA) platform show that electrical stimulation can provoke the generation of spiral waves in cardiac tissue. Nevertheless, the conditions leading to this artificial fibrillation state remain unclear. In order to have a better understanding of this phenomenon, a numerical simulation study has been conducted. The results obtained with a two-dimensional FitzHugh-Nagumo model proved that it is possible to create spiral waves by adding a stimulation current under certain conditions, which are made explicit.

yearjournalcountryeditionlanguage
2010-11-25Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
10.1109/iembs.2010.5626540https://pubmed.ncbi.nlm.nih.gov/21096190