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RESEARCH PRODUCT
Evaluation of B-cell secretion and peripheral insulin resistance during pregnancy and after delivery in gestational diabetes mellitus with obesity
Claudio CangemiBotta RmGiandomenico BompianiMaria C. AngelicoM. DonatelliMaria Pia AmatoD. Sinagrasubject
Blood GlucoseAdultmedicine.medical_specialtyEndocrinology Diabetes and Metabolismmedicine.medical_treatmentPregnancy in DiabeticsObesity; Glucose Tolerance Test; Reference Values; Humans; Diabetes Mellitus; Islets of Langerhans; Insulin; Blood Glucose; Pregnancy; Puerperal Disorders; Adult; Insulin Resistance; Female; Pregnancy in DiabeticsIslets of LangerhansEndocrinologyInsulin resistanceReference ValuesPregnancyDiabetes mellitusInternal medicineInternal MedicinemedicineDiabetes MellitusHumansInsulinObesityPregnancyGlucose tolerance testSettore MED/12 - Gastroenterologiamedicine.diagnostic_testbusiness.industryInsulinGeneral MedicinePuerperal DisordersGlucose clamp techniqueGlucose Tolerance Testmedicine.diseaseGestational diabetesEndocrinologyGestationFemaleInsulin Resistancebusinessdescription
Nine pregnant women with gestational diabetes mellitus (GDM) were studied. Six normal pregnant women and six normal nonpregnant women were evaluated as control groups. All the women underwent oral glucose tolerance test and glucose clamp during the third trimester of pregnancy and two months after delivery. During OGTT, glucose, C-peptide and insulin plasma levels were determined. C-peptide and insulin values in the late phase of OGTT were higher during pregnancy than after delivery in both groups. In gestational diabetic women, the M-value in the second steady-state during glucose clamp was lower than in controls, both during pregnancy and after delivery. Nevertheless, in both groups the M-value during pregnancy was lower than after delivery. Moreover, in gestational diabetic women there was an inverse correlation between M-value in the second steady-state and ponderal excess index after delivery. In conclusion, the impaired peripheral glucose utilization and the pancreatic pattern of gestational diabetic women compared to normal suggested altered B-cell secretion response, increased peripheral resistance and overweight to be the main changes in GDM.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1988-01-01 |