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RESEARCH PRODUCT
Coffee Silverskin and Spent Coffee Suitable as Neuroprotectors against Cell Death by Beauvericin and α-Zearalenol: Evaluating Strategies of Treatment
Gianni SagratiniCristina JuanAna Juan-garcíaGiovanni CaprioliJordi Mañessubject
Programmed cell deathTime Factors030309 nutrition & dieteticsHealth Toxicology and Mutagenesislcsh:MedicineToxicologyCoffeeArticleSH-SY5Y cells03 medical and health scienceschemistry.chemical_compoundInhibitory Concentration 500404 agricultural biotechnologyCell Line TumorDepsipeptidesIc50 valuesHumansViability assayFood scienceCytotoxicityMycotoxinNeuroblastoma cell linespent coffeeNeurons0303 health sciencesCell DeathDose-Response Relationship DrugPlant Extractslcsh:Rbeauvericin04 agricultural and veterinary sciences040401 food scienceCytoprotectionBeauvericinNeuroprotective AgentschemistryCytoprotectionSeedsZeranolα-zearalenolcoffee silverskindescription
Coffee silverskin and spent coffee have been evaluated in a neuroblastoma cell line (SH-SY5Y cells) against beauvericin (BEA) and α-zearalenol (α-ZEL)-induced cytotoxicity with different strategies of treatment. First, the direct treatment of mycotoxins and coffee by-products extracts in SH-SY5Y cells was assayed. IC50 values for α-ZEL were 20.8 and 14.0 µM for 48 h and 72 h, respectively and, for BEA only at 72 h, it was 2.5 µM. Afterwards, the pre-treatment with spent coffee obtained by boiling water increased cell viability for α-ZEL at 24 h and 48 h from 10% to 16% and from 25% to 30%, respectively
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-02-01 | Toxins |