6533b828fe1ef96bd1289014
RESEARCH PRODUCT
Novel oxybispyridylboronic acids: synthesis and study of their reactivity in Suzuki-type cross-coupling reactions
Inmaculada BerenguerAlexandre BouillonSylvain RaultAurélien LesnardJean-charles LancelotAnne Sophie Voisinsubject
inorganic chemicalschemistry.chemical_compoundchemistryArylOrganic ChemistryDrug DiscoveryOrganic chemistryHalideReactivity (chemistry)General MedicineBiochemistryCombinatorial chemistryCoupling reactiondescription
Abstract This paper sets forth the synthesis of novel oxybispyridylboronic acids, which are prepared from the corresponding halo-oxybispyridines via halogen–metal exchange using n-butyllithium and treatment with triisopropylborate. A range of efficient cross-coupling reactions of these novel boronic acids with selected aryl halides is described. This strategy produces novel pyridylethers of interest in cholinergic medicinal chemistry.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-03-20 | Tetrahedron |